In children, osteomalacia may result from a deficiency of which vitamin?

Osteomalacia, which refers to the softening of bones due to a failure in the mineralization process, is primarily associated with a deficiency of Vitamin D. In children, this condition manifests as rickets, where inadequate Vitamin D leads to decreased calcium absorption in the intestine and subsequently weakens bone structure.

Vitamin D is crucial for calcium and phosphate metabolism, both of which are essential for maintaining healthy bone mineralization. Without sufficient Vitamin D, bones can become softer and more pliable, increasing the risk of deformities and fractures. This vitamin can be synthesized by the body when exposed to sunlight, but dietary intake is also vital, particularly in populations with limited sun exposure or dietary sources of Vitamin D.

Other vitamins mentioned, such as Vitamin C, Vitamin A, and Vitamin K, play important roles in overall health and well-being, but they are not directly linked to the pathological processes involved in osteomalacia. For example, Vitamin C is important for collagen synthesis, Vitamin A is crucial for vision and immune function, and Vitamin K is essential for blood clotting and bone metabolism, but they do not specifically prevent bone softening in the way Vitamin D does. Therefore, Vitamin D deficiency is the primary concern when considering osteomalacia in children.