What condition is Mikulicz disease closely associated with?

Mikulicz disease is closely associated with Sjögren's syndrome, which is an autoimmune condition characterized by inflammation and damage to the exocrine glands, particularly the salivary and lacrimal glands. This results in the hallmark symptoms of dry mouth (xerostomia) and dry eyes due to reduced secretion of saliva and tears.

The association of Mikulicz disease with Sjögren's syndrome is significant because Mikulicz disease presents as enlargement of these glands, often leading to the same symptoms of xerostomia. In patients with Sjögren's syndrome, the swelling of the salivary glands can be pronounced and may give rise to clinical presentations resembling Mikulicz disease.

Thus, when considering Mikulicz disease, understanding its relationship with Sjögren's syndrome is crucial for diagnosis, management, and treatment, making it the most relevant condition linked to Mikulicz disease in this context.