What developmental anomaly is associated with McCune-Albright syndrome?

McCune-Albright syndrome is characterized by a triad of symptoms: fibrous dysplasia of bone, skin pigmentation (café-au-lait macules), and endocrine abnormalities. The correct answer reflects the comprehensive nature of the syndrome, which is not limited to a single bone involvement but rather involves multiple bones affected by fibrous dysplasia, alongside significant endocrine dysfunction.

In this context, fibrous dysplasia occurs when normal bone is replaced with fibrous tissue, leading to bone deformities and fracture risks. Importantly, McCune-Albright syndrome is also associated with hormonal changes, such as precocious puberty, hyperthyroidism, or other endocrine disorders, which further distinguish it from other conditions related to bone anomalies.

Alternatively, while single bone fibrous dysplasia might seem plausible, it does not encompass the full spectrum of manifestations seen in McCune-Albright syndrome, which includes multiple bones and significant systemic involvement. Dental cysts and malignant tumors of the bone are not primary features of McCune-Albright syndrome, making the correct response about multiple bones and endocrine involvement the most accurate representation of this syndrome.