What disease is primarily associated with delayed tooth eruption and retention of primary teeth?

The correct answer is cleidocranial dysplasia, which is a genetic disorder that significantly impacts the development of bones and teeth. One of the hallmark features of this condition is the delayed eruption of permanent teeth and the retention of primary teeth. Individuals with cleidocranial dysplasia often have missing or underdeveloped collars on their teeth due to the abnormal development of the dental follicles, leading to an overall delay in achieving the normal dental pattern.

This condition is caused by mutations in the RUNX2 gene, which plays a crucial role in bone and tooth development. The clinical manifestations include not only dental abnormalities but also skeletal anomalies such as hypoplasia of the clavicles, widening of the suture lines in the skull, and features associated with short stature.

Other options listed have different primary characteristics. Osteomalacia typically involves softening of the bones due to vitamin D deficiency and does not specifically relate to tooth eruption. Cleft palate primarily affects the oral cavity and may be associated with dental anomalies, but it does not specifically cause delayed eruption of teeth. Hypophosphatasia affects bone mineralization and can lead to tooth loss, but it does not specifically describe the retention of primary teeth as a key feature. Therefore, cle