What is a common presentation of Hairy Leukoplakia in immunocompromised patients?

A white, rough patch on the lateral border of the tongue is the hallmark presentation of Hairy Leukoplakia, particularly in immunocompromised individuals, such as those with HIV/AIDS. This condition is caused by Epstein-Barr virus (EBV) and is uniquely characterized by its appearance and location. The lesions are often asymptomatic and may be mistaken for other conditions, but the rough, hairy appearance distinctly sets it apart.

In immunocompromised patients, the immune system is less capable of controlling the replication of EBV, leading to this specific manifestation. In contrast to other presentations, the location of the lesions on the lateral borders of the tongue, along with their white, hairy appearance, provides a clear diagnostic clue that aligns with Hairy Leukoplakia. Other lesions mentioned, such as smooth, red lesions or yellowish coatings, do not reflect the characteristic texture or typical sites for Hairy Leukoplakia. Therefore, the identification of a white, rough patch on the lateral aspects of the tongue is essential for recognizing this condition in at-risk populations.