What symptom is commonly associated with Plummer's disease?

Plummer's disease, also known as toxic multinodular goiter, is characterized by the presence of multiple adenomas within the thyroid gland that lead to an overproduction of thyroid hormones. This results in hyperthyroidism symptoms and often presents with a goiter. The key feature of Plummer's disease is indeed the presence of these multiple toxic adenomas, which are distinct from other forms of hyperthyroidism, such as Graves' disease, where exophthalmos and diffuse goiter are more common.

In Plummer's disease, the nodules in the thyroid can autonomously produce excess thyroid hormones, which contribute to symptoms like increased heart rate, weight loss, and anxiety rather than weight gain or fatigue. The presence of multiple adenomas is the hallmark of this condition, differentiating it from other thyroid-related disorders. Understanding the typical presentation and underlying mechanisms of Plummer's disease is essential for recognizing and diagnosing this condition in clinical practice.