What type of skin changes are commonly seen in Peutz-Jeghers syndrome?

In Peutz-Jeghers syndrome, the most notable skin changes include freckle-like spots that typically appear on the lips and within the oral mucosa. These spots, known as lentigines, are usually pigmented lesions that develop in childhood or adolescence and can persist throughout life. They are a hallmark feature of the syndrome and are linked to the genetic mutations associated with Peutz-Jeghers syndrome, which is characterized by multiple hamartomatous polyps and an increased risk of various cancers.

The presence of these spots is significant as they can aid in the clinical diagnosis of the syndrome. Recognizing these freckle-like spots is crucial for healthcare professionals when assessing patients who may exhibit gastrointestinal symptoms or have a family history suggestive of this genetic condition.